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Melanotan II, 10mg
Melanotan II is a synthetic cyclic heptapeptide analogue of α-melanocyte-stimulating hormone (α-MSH), engineered for enhanced receptor affinity and metabolic stability.
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Melanotan II is a synthetic cyclic heptapeptide analogue of α-melanocyte-stimulating hormone (α-MSH), engineered for enhanced receptor affinity and metabolic stability. The compound functions as a non-selective agonist of the melanocortin receptor family, exhibiting activity across multiple receptor subtypes including MC1R, MC3R, MC4R, and MC5R.
Its broad receptor interaction profile has made it a valuable tool for investigating melanocortin receptor pharmacology, ligand-receptor binding dynamics, receptor activation mechanisms, and subtype-specific signaling pathways.
Research applications include melanocortin receptor characterization, receptor selectivity investigations, structure-activity relationship studies, and comparative analyses of melanocortin receptor agonists.
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3D Molecular Structure
Drag to rotate · scroll to zoom| Chemical Formula | C50H69N15O9 |
|---|---|
| Synonyms | MT-II, Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2 |
| Molar Mass | 1,024.2 g/mol |
| CAS Number | 121062-08-6 |
| PubChem CID | 92432 |
| Total Compound Content | 10 mg per vial |
| Shelf Life | 36 months |
Melanotan II (Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2) is a synthetic cyclic heptapeptide analogue of α-melanocyte-stimulating hormone (α-MSH) engineered for enhanced receptor affinity and metabolic stability. The cyclic lactam structure contributes to resistance against enzymatic degradation and prolonged receptor engagement relative to linear melanocortin peptides. Melanotan II functions as a non-selective agonist of the melanocortin receptor family, exhibiting high-affinity interactions with MC1R, MC3R, MC4R, and MC5R receptor subtypes.
Receptor activation initiates melanocortin-associated signaling pathways involving G protein-coupled receptor activation, intracellular cAMP generation, and downstream transcriptional regulatory processes. Its broad receptor interaction profile has established Melanotan II as a valuable research tool for investigating melanocortin receptor pharmacology, receptor subtype selectivity, ligand-receptor binding dynamics, and structure-activity relationships within the melanocortin system. Research applications include receptor characterization studies, signaling pathway investigations, comparative analyses of melanocortin receptor agonists, and mechanistic evaluation of receptor-mediated signal transduction. Supplied as a lyophilized preparation (10 mg/vial). Independently third-party HPLC-tested; COA available per batch.
Results refer to the tested sample. Check the batch and date in the report.
Which melanocortin receptor subtypes does Melanotan II interact with?
Melanotan II exhibits high-affinity interactions with multiple melanocortin receptor subtypes, including MC1R, MC3R, MC4R, and MC5R. This broad receptor activity profile has made it a valuable research tool for investigating receptor subtype pharmacology, ligand-receptor binding dynamics, signaling pathway activation, and comparative analyses of melanocortin receptor function.
Its non-selective nature allows researchers to examine receptor-specific signaling characteristics across multiple members of the melanocortin receptor family.
What structural features contribute to the stability of Melanotan II?
Melanotan II incorporates a cyclic lactam structure and strategic amino acid modifications that enhance resistance to enzymatic degradation relative to linear melanocortin peptides. These structural characteristics contribute to prolonged receptor engagement and have made Melanotan II a useful model compound for investigating peptide stability, ligand design, receptor affinity optimization, and structure-activity relationships within the melanocortin system.
How does Melanotan II differ from other melanocortin receptor agonists?
Melanotan II is characterized by broad activity across multiple melanocortin receptor subtypes together with enhanced metabolic stability and a well-defined pharmacological profile. These properties have established it as a widely used reference compound in studies examining melanocortin receptor signaling, receptor selectivity, ligand-receptor interactions, and comparative pharmacology among melanocortin receptor agonists and related peptide analogues.
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Highly recommend the fast turnaround times, purity exceeded my expectations. A trustworthy supplier. Our research results are completely exceeding expectations.
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Exceptional service on the prompt communication, the quality is absolutely top-tier. Great value. My laboratory research results exceeded expectations.
