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Product Usage: This product is intended for research purposes only.
All product information available on this website is for educational purposes only. Any form of bodily introduction into humans or animals is strictly prohibited by law. This product should only be handled by licensed and qualified professionals. It is not a drug, food, or cosmetic, and must not be misbranded, misused, or mislabeled as such.
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IGF-1 DES 1 mg
IGF-1 DES (Des(1-3)IGF-1) is a naturally occurring, endogenous truncated form of IGF-1 lacking the first three N-terminal amino acids.
$55.95 – $559.50
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IGF-1 DES (Des(1-3)IGF-1) is a naturally occurring, endogenous truncated form of IGF-1 lacking the first three N-terminal amino acids. This truncation reduces IGFBP affinity by approximately 10-fold relative to native IGF-1 while modestly increasing IGF-1 receptor binding potency.
The shorter half-life and higher local potency of IGF-1 DES make it a useful research tool for studying IGF-1R activation dynamics distinct from the longer-acting IGF-1 LR3 analogue.
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- Independently Lab Tested
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- For Laboratory Research Use Only
All Prime Peptides products are independently third-party tested at a USA-based HPLC-licensed laboratory prior to distribution. Certificates of Analysis (COA) are published on the Independent Test Results page and available at product level. If any independently conducted HPLC test returns a negative result, Prime Peptides will refund: (1) the cost of the HPLC test, and (2) the full order amount including shipping.
| Chemical Formula | C319H501N91O96S7 |
|---|---|
| Synonyms | IGF1 Human Des1-3; Insulin-Like Growth Factor 1 Des (1-3) Human Recombinant; Somatomedin C; IGF-I; IGFI; IGF1; IGF-IA; Des(1-3); Des1-3; Des 1-3; Des (1-3); IGF-1 (4-70); IGF1 Des1-3 |
| Molar Mass | 7,649 g/mol |
| CAS Number | 112603-35-7 |
| Total Compound Content | 1 mg per vial |
| Shelf Life | 36 months |
IGF-1 DES is a truncated analogue of insulin-like growth factor 1 (IGF-1) in which the three N-terminal amino acids are absent relative to the full-length peptide. This structural modification alters its interaction profile with insulin-like growth factor binding proteins (IGFBPs), resulting in a greater proportion of unbound peptide available for receptor interaction. IGF-1 DES retains high-affinity binding to the insulin-like growth factor 1 receptor (IGF-1R) and preserves activation of downstream receptor-mediated signaling pathways, including PI3K/Akt/mTOR and MAPK/ERK cascades. The modified structure and distinct receptor-accessibility profile make IGF-1 DES a valuable research tool for investigating IGF-1R pharmacology, ligand-receptor interactions, growth factor signaling mechanisms, and comparative studies of IGF-1 analogues. Supplied as a lyophilized preparation (1 mg/vial). Independently third-party HPLC-tested; COA available per batch.
Every batch is independently lab tested for identity, purity and potency. View our lab testing program →
How does IGF-1 DES differ from IGF-1 LR3 in terms of receptor interaction characteristics?
IGF-1 DES and IGF-1 LR3 are structurally modified forms of IGF-1 that differ in their interactions with insulin-like growth factor binding proteins (IGFBPs) and their resulting receptor-accessibility profiles. IGF-1 DES utilizes N-terminal truncation, whereas IGF-1 LR3 incorporates amino acid substitution and sequence extension.
These structural differences make both compounds useful research tools for investigating IGFBP interactions, ligand-receptor dynamics, and comparative IGF-1 receptor pharmacology.
What distinguishes IGF-1 DES from full-length IGF-1?
IGF-1 DES is a truncated analogue of IGF-1 in which the N-terminal region has been modified relative to the full-length peptide. This structural change alters its interaction characteristics while preserving high-affinity binding to the insulin-like growth factor 1 receptor (IGF-1R).
As a result, IGF-1 DES is frequently used in studies examining structure-function relationships, receptor activation mechanisms, and the influence of peptide architecture on growth factor signaling pathways.
Why is IGF-1 DES useful for growth factor signaling research?
IGF-1 DES retains activation of key IGF-1R-mediated signaling pathways, including PI3K/Akt/mTOR and MAPK/ERK regulatory cascades. Its modified structure and distinct interaction profile make it a valuable research tool for investigating ligand-receptor interactions, growth factor signaling mechanisms, receptor pharmacology, and comparative studies of IGF-1 analogues and related signaling systems.
Customer Reviews (10)
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Verified Buyer
This co has a great customer service and great DES. I will be ordering again. Tnx!
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Verified Buyer
Great Product! Good Price! Fast Delivery! Doesn't get any better.
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Verified Buyer
I had a query relating to the delivery of the item. My question was answered within minutes with a very helpful response. The item were very carefully packaged and neatly arranged. Will definately be using IGF-1 DES 1MG again.
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Verified Buyer
Very happy with the product
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Verified Buyer
We got fantastic research results. Highly recommend the prompt communication, the chemical quality is top notch. Great value.
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Verified Buyer
Great quality on the support team and it's an exceptionally pure batch. Highly consistent test results. Highly recommend this vendor.
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Verified Buyer
Top-notch quality from the customer service and quality was great and dispatch was incredibly fast. My laboratory research results exceeded expectations. Excellent all-round service.
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Verified Buyer
Super happy with the super fast shipping, the compound is pure and high quality. Our research results are completely exceeding expectations. Excellent all-round service.
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Verified Buyer
Service is an impressive and higher standard. I would love to re-order soon.
